Following his time as a reservist in the Gulf War, Pimentel left the service to earn a bachelor’s degree in industrial microbiology and a master’s degree in biology from the University of Puerto Rico.
Pimentel then braved the cold climate of Pullman, Washington to earn a doctoral degree in plant pathology from Washington State University (WSU), focusing on mycology and population genetics. Following his graduation from WSU, Pimentel, now a lieutenant, became head of the microbiology department at the U.S. Naval Medical Center in Portsmouth, Virginia.
From 2003 to 2010, Pimentel served multiple leadership positions at the Naval Medical Research Unit (NAMRU) 3 (now NAMRU EURAFCENT), then located in Cairo. In these roles, he managed research projects with the mission of implementing and strengthening laboratory-based disease surveillance capabilities in the Middle East, Central Asia, former Soviet Union, North Africa and West Africa. Pimentel led research and surveillance efforts to understand the epidemiology of infectious diseases of public health importance in the EUCOM, CENTCOM and AFRICOM Areas of Responsibility. He went on to provide laboratory support during several H5N1 flu outbreaks in West Africa and Central Asia. During the 2009 H1N1 pandemic, Pimentel led the NAMRU-3 outbreak support to forces deployed in Afghanistan, Iraq and 20 partner nations.