Posted on Oct 2, 2023
The brain cells linked to protection against dementia
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https://www.nature.com/articles/d4 [login to see] 2-7?utm_placement=newsletter
The scientists identified two key cell types that had a specific genetic marker. One had active genes coding for reelin, a protein associated with brain disorders such as schizophrenia, and the other had active genes that code for somatostatin, a hormone that regulates processes throughout the body. People who had greater levels of cognitive impairment, the researchers found, had relatively low numbers of these cells. Those who had no cognitive impairment had high numbers of the cells, even if they also had large amounts of amyloid in their brains that would typically denote Alzheimer’s. This suggests that these cell types protect the brain against the disease’s symptoms.
The scientists identified two key cell types that had a specific genetic marker. One had active genes coding for reelin, a protein associated with brain disorders such as schizophrenia, and the other had active genes that code for somatostatin, a hormone that regulates processes throughout the body. People who had greater levels of cognitive impairment, the researchers found, had relatively low numbers of these cells. Those who had no cognitive impairment had high numbers of the cells, even if they also had large amounts of amyloid in their brains that would typically denote Alzheimer’s. This suggests that these cell types protect the brain against the disease’s symptoms.
The brain cells linked to protection against dementia
Posted from nature.com
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Posted 1 y ago
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It's a wicked condition. I hope that they can use this information and come up with something to prevent dementia. We've lost too many family members that are still here physically, but have no idea who people are anymore. It frustrates them and their loved ones.
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My Mom's Younger brother and sister both died from Alzheimer's and so did My Dad's brother at age 90 My Dad on the other hand was still very sharp even at age 97. Mom was fine in that respect and lived to age 90. My Great Grandfather died from Dementia but before I was born, so I never knew Him. My own brother, now 69 has had Paranoid Schizophrenia for the last 25 years. All were overachievers and very well educated. I sure hope We don't see any more of that in our family but its apparently more common than most are aware of. That is not an easy thing for any family to have to deal with.
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So now we have reelin, a protein associated with brain disorders such as schizophrenia and somatostatin, a hormone that regulates processes throughout the body. People who had greater levels of cognitive impairment, the researchers found, had relatively low numbers of these cells. Needless to say, both proteins were mysteriously missing on the White House's test rats...
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