Scientists sequence Beethoven's genome for clues into his painful past

https://www.npr.org/sections/health-shots/2023/03/22/ [login to see] /scientists-sequence-beethovens-genome-for-clues-into-his-painful-past
Ludwig van Beethoven lived a life of pain. His suffering was so great that in 1802 — while only in his early 30's — the classical composer and pianist penned a letter to his brothers describing how his maladies had soured his demeanor and isolated him from society.

In this message, known as the Heiligenstadt Testament, Beethoven asked that the physical ailments that plagued him in life be publicized after his death.

"As soon as I am dead if Dr. Schmid is still alive ask him in my name to describe my malady and attach this document to the history of my illness so that so far as possible at least the world may become reconciled with me after my death," he wrote in his native German.