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On December 12, 1787, Pennsylvania becomes the second state to ratify the Constitution, by a vote of 46 to 23. Pennsylvania was the first large state to ratify, as well as the first state to endure a serious Anti-Federalist challenge to ratification. Pennsylvania was the most ethnically and religiously diverse state in the new nation. One-third of Pennsylvania’s population was German-speaking, and the Constitution was printed in German for the purposes of involving that population in the debate. The chairman of the Pennsylvania ratifying convention, Reverend Frederick Augustus Conrad Muhlenberg, was the son of the leading German Lutheran minister and grandson to Conrad Weiser (1696-1760), who had been a leading colonial Indian interpreter and German-speaking political leader. The leader of the Anti-Federalist opposition was the Delaware-born Scots-Irishman Thomas McKean. Future Supreme Court Justice and Scottish immigrant James Wilson was the most articulate defender of the Federalist cause.