On the night of June 30, 1520, Spanish conquistadors were expelled from Tenochtitlan following an Aztec revolt against their rule under Hernán Cortés It became known as "La Noche Triste" (the Night of Sadness). An excerpt from the article:
"On his return to Tenochtitlan, Cortés discovered Alvarado had indulged in an unprovoked massacre of the Aztecs, stirring the previously docile populace to murderous fury. The Spaniards quickly found themselves trapped and besieged in the capital, and hard fighting in the streets failed to subdue the enemy. Not even Montezuma could soothe his people, who met their emperor’s appeal for peace with a shower of stones that mortally wounded him. With the Spanish force growing short of food and water, and losing more men by the day, Cortés decided to withdraw from the city on the night of June 30–July 1. After a brutal running fight along a causeway leading to shore, the column was reduced to a tattered remnant, leaving Cortés with no more than one-fifth of the force he had originally led into Tenochtitlan. The overnight battle—the worst military disaster the conquistadors had suffered in the New World—would go down in Spanish history as La Noche Triste (“The Night of Sorrows”).
The debacle left Cortés with few materiel advantages. Only half of his horses survived, and the column had lost all of its powder, ammunition and artillery and most of its crossbows and harquebuses during the retreat. Yet the Spanish commander managed to hold together his flagging force. Skirting north to avoid a cluster of hostile villages, he headed toward Tlaxcala, home city of his Mesoamerican allies.
Over the days that followed Aztec skirmishers shadowed Cortés’ retreating column, and as the Spaniards neared the Tlaxcalan frontier, the skirmishers joined forces with warriors from Tenochtitlan and assembled on the plain of Otumba, between the conquistadors and their refuge. The trap thus set, on July 7 the numerically superior Aztecs and beleaguered Spaniards met in a battle that should easily have gone in the Mesoamericans’ favor. Again, however, Cortés turned the tables by skillfully using his remaining cavalry to break up the enemy formations. Then, in a daring stroke, he personally led a determined cavalry charge that targeted the enemy commander, killing him and capturing his colors. Seeing their leader slain, the Aztecs gradually fell back, ultimately enabling the conquistadors to push their way through. Though exhausted, starving and ill, they were soon among allies and safe from assault."