USS Preble (DLG-15/DDG-46) was a Farragut-class guided missile destroyer in the United States Navy. She was the fifth, of now six ships, named to honor Commodore Edward Preble (1761–1807). Preble was laid down by Bath Iron Works of Bath, Maine on 16 December 1957. She was launched on 23 May 1959, sponsored by Mrs. Ralph E. Wilson. Preble was commissioned at the Boston Naval Shipyard on 9 May 1960, Commander Edward G. Fitz-Patrick in command. She was decommissioned on 15 November 1991 and struck 20 November 1992 to be scrapped.