Immune Checkpoint Assays - Creative Biolabs

A class of membrane proteins known as immune checkpoints is expressed on effector cells, such as T/B cells and NK cells, and is made up of several co-inhibitory and co-stimulatory pathways. They are engaged in the process of getting rid of undesirable substances while preserving their own tolerance, which is vital for immunological control.
Immune checkpoints can be broadly classified into two categories: activating and inhibitory receptors. Thus, it is possible to characterize the two primary mechanisms of immunotherapeutic antibodies as route enhancement (agonists) and pathway blockage (antagonists).