BBC - History - Edward Jenner

On May 14, 1796, English country doctor Edward Jenner administered the first inoculation against smallpox, using cowpox pus, in Berkeley, Gloucestershire. From the article:

"Jenner was an English doctor, the pioneer of smallpox vaccination and the father of immunology.

Edward Jenner was born in Berkeley, Gloucestershire on 17 May 1749, the son of the local vicar. At the age of 14, he was apprenticed to a local surgeon and then trained in London. In 1772, he returned to Berkeley and spent most the rest of his career as a doctor in his native town.

In 1796, he carried out his now famous experiment on eight-year-old James Phipps. Jenner inserted pus taken from a cowpox pustule and inserted it into an incision on the boy's arm. He was testing his theory, drawn from the folklore of the countryside, that milkmaids who suffered the mild disease of cowpox never contracted smallpox, one of the greatest killers of the period, particularly among children. Jenner subsequently proved that having been inoculated with cowpox Phipps was immune to smallpox. He submitted a paper to the Royal Society in 1797 describing his experiment, but was told that his ideas were too revolutionary and that he needed more proof. Undaunted, Jenner experimented on several other children, including his own 11-month-old son. In 1798, the results were finally published and Jenner coined the word vaccine from the Latin 'vacca' for cow.

Jenner was widely ridiculed. Critics, especially the clergy, claimed it was repulsive and ungodly to inocculate someone with material from a diseased animal. A satirical cartoon of 1802 showed people who had been vaccinated sprouting cow's heads. But the obvious advantages of vaccination and the protection it provided won out, and vaccination soon became widespread. Jenner became famous and now spent much of his time researching and advising on developments in his vaccine. Jenner carried out research in a number of other areas of medicine and was also keen on fossil collecting and horticulture. He died on 26 January 1823."