A "closed diffuse axonal injury" refers to a traumatic brain injury where the brain experiences widespread damage to its nerve fibers (axons) due to a forceful shaking or rotational movement within the skull, without any open skull fracture, causing disruption in brain communication and potentially leading to coma or cognitive impairment; essentially, a severe closed head injury with microscopic damage to the brain's white matter tracts, most commonly caused by high-impact accidents like car crashes.
Key points about closed diffuse axonal injury:
Mechanism:
When the head is rapidly accelerated or decelerated, the brain inside the skull moves differently, causing the delicate axons to stretch and tear, leading to damage across a large area of the brain.
Symptoms:
Depending on the severity, symptoms can include immediate loss of consciousness, coma, confusion, memory problems, difficulty with motor skills, impaired cognitive function, and vegetative state.