On October 6, 68 BC, at the Battle of Artaxata, Lucullus averted the bad omen of this day by defeating Tigranes the Great of Armenia. An excerpt from the article:
"The Roman Republic saw the danger of such an alliance between the two regional powers, a suspicion which was confirmed by a joint Tigranes-Mithridates campaign against the Roman client state of Cappadoccia. The Romans responded by attacking Pontus and when Mithridates fled to the court of Tigranes in 70 BCE they asked for the former to be handed over. When Tigranes refused, the Romans invaded Armenia. Tigranes was defeated by a Roman army commanded by the general Licinius Lucullus, Tigranocerta was besieged and, after the betrayal of the Greek garrison, captured in 69 BCE. The Armenian king was, consequently, forced to abandon his conquests. The conquering Romans were amazed at the wealth of Tigranocerta, and that after Tigranes had already managed to spirit away his royal treasury.
Lucullus then moved to attack the important city of Artaxata (Artasat) but with winter coming on, his supply line dangerously thin and exposed, and even a mutiny amongst his own troops, the Roman general was forced to withdraw. Tigranes' army harried the retreating Romans using guerrilla tactics and although Lucullus captured Nisibis, he was recalled to Rome in 67 BCE. The respite would not last for long as the Roman Senate proved determined to stamp its authority on the region once and for all.
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In 66 BCE another Roman army headed eastwards, this time led by Pompey the Great who had already won great acclaim. He had also celebrated two Roman triumphs; Pontus, Parthia and Armenia seemed as good a place as any to grab his third and a handsome load of booty to go with it. First, he attacked Pontus and sent Mithridates fleeing to the Black Sea. Next was Armenia's turn and here he was aided by Tigranes' traitorous third son, Tigranes the Younger.
Artaxata (now capital after Tigranocerta's demise) was attacked and, although it had resisted a Parthian siege the year before, quickly surrendered. Perhaps Tigranes did not want to see a repeat of the destruction at Tigranocerta and so there may not have been much actual fighting. Tigranes was now in old age and he seems to have bought off Pompey with the vast wealth he had been accumulating over a lifetime. Roman writers record that the Armenian king gave (or was made to give) 6,000 talents of silver to Pompey, 10,000 drachmas to each military tribune, 1000 drachmas for each centurion and 50 for each legionary. In these agreeable circumstances, Tigranes was permitted to retain the heartland of his kingdom trimmed of those territories he had acquired through conquest and with Sophene being given to his traitorous son - who incidentally got his comeuppance when he later insulted Pompey and so was marched to Rome for display in the general's third triumph there.
Armenia was, thus, made into a Roman protectorate but it is debatable if the empire of Tigranes, made up of such disparate and forcibly relocated populations and which was so loosely joined via tribute and coercion without much political apparatus, would have survived very long even without Roman interference. Henceforth, the Armenian state, although officially a friend and ally of the Romans, remained strategically important in the region and so was still a bone of contention between Rome and Parthia (and its successor, Sasanid Persia). Tigranes continued to rule most of Armenia quietly enough as a vassal state of the Roman Empire, acting as a useful buffer to the Parthians until his death c. 56 BCE aged around 85."