Posted on Apr 16, 2020
Anti-malaria drug pushed by Trump has no value fighting coronavirus, report claims
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This is why we should have experts doing studies on the health impact of these potential cures and not listening to grifters who are going to get Americans killed.
Anti-malaria drug pushed by Trump has no value fighting coronavirus, report claims
Posted from independent.co.ukPosted in these groups: 
Coronavirus COVID19
Coronavirus COVID19
Posted >1 y ago
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OK one non peer reviewed study that indicates that the use of hydroxychloroquine did not help much once patients lungs were already compromised. But what about those who were not as sick? Was it given by itself, or in combination with other drugs as has been the recommendation of the medical professionals who have been urging it's use. What about the studies that have delivered apposite results. Why are they not mentioned?
What we do know is that the patients who have it now can't wait six months to a year for well designed, double blind, peer reviewed tests to produce results. If anecdotal evidence indicates that a combination of known drugs may help, then they should be given. Keep in mind they are being given in a controlled setting and under medical supervision. All have been around for a long time, they are only "off label" because they have not been used for this before. For that matter neither has anything else.
What we do know is that the patients who have it now can't wait six months to a year for well designed, double blind, peer reviewed tests to produce results. If anecdotal evidence indicates that a combination of known drugs may help, then they should be given. Keep in mind they are being given in a controlled setting and under medical supervision. All have been around for a long time, they are only "off label" because they have not been used for this before. For that matter neither has anything else.
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SPC Kevin Ford
PO1 Kevin Dougherty
A good article to read on drug-disease interactions
https://study.com/academy/lesson/common-drug-disease-interactions.html
A good article to read on drug-disease interactions
https://study.com/academy/lesson/common-drug-disease-interactions.html
Common Drug-Disease Interactions | Study.com
Many drugs that are intended for therapeutic purposes can cause harmful effects when they are given to patients with certain diseases. In this...
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PO1 Kevin Dougherty
SPC Kevin Ford - Currwently there is NO approved treatment. The only currently authorized for use by the FDA is remdesivir which is a new antiviral that has not come out of the approval process for anything, but which like Hydroxychloroquine has shown promise. They are the only drugs authorized for emergency use at this time.
The side effect argument is basically null, as those side effects are possible for any of the conditions it is currently given for. Other than Malaria, they were also once "off label" treatments as well. Yes, Cardiomyopathy and some other cardiac effects as well as some other rare but serious side effects are possible, but the key word there is rare. Truth is if you really read the full warnings on any of the meds we commonly take, you would have second thoughts about taking them. Every time a doctor writes a script they are weighing the risks against the benefits. That is also key, nobody is advocating that this be given blindly or en-mass, but under the supervision of a physician who will evaluate your condition, any counter-indications, and side effects in determining what course of treatment to take.
The side effect argument is basically null, as those side effects are possible for any of the conditions it is currently given for. Other than Malaria, they were also once "off label" treatments as well. Yes, Cardiomyopathy and some other cardiac effects as well as some other rare but serious side effects are possible, but the key word there is rare. Truth is if you really read the full warnings on any of the meds we commonly take, you would have second thoughts about taking them. Every time a doctor writes a script they are weighing the risks against the benefits. That is also key, nobody is advocating that this be given blindly or en-mass, but under the supervision of a physician who will evaluate your condition, any counter-indications, and side effects in determining what course of treatment to take.
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PO1 Kevin Dougherty
Capt Gregory Prickett - I would argue that most doctors are very well versed in Pharmacology, especially as it relates to their field.
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PO1 Kevin Dougherty
Capt Gregory Prickett - Yes there can be no one has denied that there are RARE serious side effects. Lot's of drugs administered every day have rare serious side effects. All we have for anything in this case are anecdotal reports and limited studies.
The jury is still out, but it appears that the effectiveness is not the results of antiviral action, but a mechanism similar to it's antimalarial action. Malaria apparently binds to the hemoglobin in red blood cells limiting the ability of them to carry oxygen. The COVID-19 virus appears that it may act in a similar way. (They're not sure, but I saw a couple research papers suggesting that. Heck, they have been studying and treating Malaria for decades and they still don't fully understand it, or how the Quinine family of drugs combat it.) If this is the case, then it works by limiting hypoxic damage to the lungs and other organs. Time will tell. Like everything else with this damn disease, it's all pretty much edumacated guestimation.
The jury is still out, but it appears that the effectiveness is not the results of antiviral action, but a mechanism similar to it's antimalarial action. Malaria apparently binds to the hemoglobin in red blood cells limiting the ability of them to carry oxygen. The COVID-19 virus appears that it may act in a similar way. (They're not sure, but I saw a couple research papers suggesting that. Heck, they have been studying and treating Malaria for decades and they still don't fully understand it, or how the Quinine family of drugs combat it.) If this is the case, then it works by limiting hypoxic damage to the lungs and other organs. Time will tell. Like everything else with this damn disease, it's all pretty much edumacated guestimation.
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