In his first interview since it happened, Det Sgt Nick Bailey told the BBC: "Everything the kids owned, we lost all that, the cars, we lost everything."
Det Sgt Bailey came into contact with the nerve agent after being sent to the Skripals' home, where it had been sprayed on the door handle.
A perfume bottle containing the substance was later found in a bin, leading to the death of a woman who had sprayed the substance onto her wrists.
Investigators now say the bottle contained enough Novichok to potentially kill thousands of people.
Sergei Skripal and his daughter, Yulia, were found seriously ill on a bench in Salisbury on the afternoon of Sunday 4 March.
That night, Det Sgt Bailey and two colleagues were sent to their home, in a quiet suburb. Clad in full forensic suits, they were tasked with making sure there were no other casualties.