On November 9, 1494 Piero the Unfortunate of the de' Medici family, ruler of Florence, loses his power and flees the state. From the article:
"Piero di Lorenzo de' Medici was the eldest son of Lorenzo de' Medici (Lorenzo the Magnificent) and Clarice Orsini. He was raised with alongside his younger brother Giovanni, who would go on to become Pope Leo X, and his cousin Giulio, who would later become Pope Clement VII. [1]
He was educated to succeed his father as head of the Medici family and de facto ruler of the Florentine state, under notable figures such as Angelo Poliziano or Ficino.[3] However, his feeble, arrogant, and undisciplined character was to prove unsuited to such a role. Poliziano later died poisoned by Piero on 24 September 1494.[4]
Piero took over as leader of Florence in 1492, upon Lorenzo's death. After a brief period of relative calm, the fragile pacific equilibrium between the Italian states, laboriously constructed by Piero's father, collapsed in 1494 with the decision of King Charles VIII of France to cross the Alps with an army in order to assert hereditary claims to the Kingdom of Naples. Charles had been lured to Italy by Ludovico Sforza (Ludovico il Moro), ex-regent of Milan, as a way to eject Ludovico's nephew Gian Galeazzo Sforza and replace him as duke.
After settling matters in Milan, Charles moved towards Naples. He needed to pass through Tuscany, as well as leave troops there to secure his lines of communication with Milan. Piero attempted to stay neutral, but this was unacceptable to Charles, who intended to invade Tuscany. Piero attempted to mount a resistance, but received little support from members of Florentine elites who had fallen under the influence of the fanatical Dominican priest Girolamo Savonarola; even his cousins defected to Charles's side.
Piero quickly gave up as Charles's army neared Florence and surrendered the chief fortresses of Tuscany to the invading army, giving Charles everything he demanded. His poor handling of the situation and failure to negotiate better terms led to an uproar in Florence, and the Medici family fled. The family palazzo was looted, and the substance as well as the form of the Republic of Florence was re-established with the Medici formally exiled. A member of the Medici family was not to rule Florence again until 1512, after Giovanni de' Medici was elected Pope Leo X.
Piero and his family fled at first to Venice with the aid of the French diplomat Philippe de Commines, a retainer of Charles VIII. In 1503, as the French and Spanish continued their struggle in Italy over the Kingdom of Naples, Piero was drowned in the Garigliano River while attempting to flee the aftermath of the Battle of Garigliano, which the French (with whom he was allied) had lost."