Do permanent profiles affect a Soldier's chances of being selected for promotion?

Absolutely not. For as long as the soldier continues to display that he/she is able to achieve higher standards. I was selected for promotion to both, SFC and MSG with a P2. Why? I continue to score 90+ on my push ups. I do things that show that I am physically fit for duty. I am not able to do sit ups, but I do compete in 5ks when possible. Have you ever biked 600 miles on a weekend?? Win a bench press competition? There are a plethora of other physical challenges that can show that you are fit, and combat ready.

In my experience, it really depends on a few things. I've watched as soldiers who work desk MOSs and their careers didn't slow down much due to temporary profile limitations. However, I have watched many of my scout and tanker brother's get stone walled at SSG and they were more than qualified to move up the ladder. I think that it all really depends on the MOS of the soldier and what the particular limitations may be. Even though regulation states that if it doesn't interfere with the ability to pass a pt test that it shouldn't reflect negatively, we all know just how far some of those regulations really get followed...

I don't think so. I spent 4 1/2 years as a Specialist with a PULHES of 111111. I got diagnosed with osteoarthritis in 2010, and my PULHES changed to 112111. I was on a permanent walk at own pace and distance profile. By late 2012 I was promoted to Sergeant. In 2014 I was promoted to Staff Sergeant.

If you do what you truly can, and show that you are not shamming, leadership notices and you move up. It's just those who use their profile to sham tend to be less than stellar performers in other areas of their military lives, and do not get promoted because of *that* and NOT because of their profile.