Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results | NEJM

CONCLUSIONS
These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay. (Funded by the World Health Organization; ISRCTN Registry number, ISRCTN83971151. opens in new tab; ClinicalTrials.gov number, NCT04315948. opens in new tab.)

OUTCOMES
The protocol-specified primary objective was to assess effects on in-hospital mortality (i.e., death during the original hospitalization; follow-up ceased at discharge), regardless of whether death occurred before or after day 28. The only protocol-specified secondary outcomes were the initiation of mechanical ventilation and hospitalization duration. Although no placebos were used, appropriate analyses of these secondary outcomes can still be informative. Add-on studies that were led from Canada, France, India, and Norway recorded other outcomes (not reported here).